| dc.contributor.author | Özkahraman, Bengi | |
| dc.contributor.author | Tamahkar, Emel | |
| dc.contributor.author | İdil, Neslihan | |
| dc.contributor.author | Kılıç Süloğlu, Aysun | |
| dc.contributor.author | Perçin, Işık | |
| dc.date.accessioned | 2021-11-01T15:05:48Z | |
| dc.date.available | 2021-11-01T15:05:48Z | |
| dc.date.issued | 2021 | |
| dc.identifier.citation | Özkahraman, B., Tamahkar, E., İdil, N., Kılıç Suloglu, A., & Perçin, I. (2021). Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release. Drug Development Research, 82(2), 241-250. | en_US |
| dc.identifier.issn | 0272-4391 | |
| dc.identifier.issn | 1098-2299 | |
| dc.identifier.uri | https://doi.org/10.1002/ddr.21747 | |
| dc.identifier.uri | https://hdl.handle.net/11491/7407 | |
| dc.description.abstract | The development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified. | en_US |
| dc.description.sponsorship | Hitit University Scientific and Technical Application and Research Center | en_US |
| dc.description.sponsorship | The authors are grateful to the support of Hitit University Scientific and Technical Application and Research Center. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.ispartof | Drug Development Research | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Antibiotic Release | en_US |
| dc.subject | Chitosan-gelatin Hydrogels | en_US |
| dc.subject | Hyaluronic Acid Nanoparticles Embedding | en_US |
| dc.title | Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release | en_US |
| dc.type | article | en_US |
| dc.department | Hitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü | en_US |
| dc.department | Hitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü | en_US |
| dc.authorid | Kılıç Süloğlu, Aysun / 0000-0003-0914-1128 | |
| dc.authorid | Tamahkar, Emel / 0000-0002-5913-8333 | |
| dc.authorid | Perçin, Işık / 0000-0002-9453-4462 | |
| dc.identifier.volume | 82 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 241 | en_US |
| dc.identifier.endpage | 250 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.department-temp | [Ozkahraman, Bengi] Hitit Univ, Dept Polymer Engn, Corum, Turkey; [Tamahkar, Emel] Hitit Univ, Dept Chem Engn, Corum, Turkey; [Tamahkar, Emel] Balikesir Univ, Dept Food Engn, Balikesir, Turkey; [Idil, Neslihan; Kilic Suloglu, Aysun; Percin, Isik] Hacettepe Univ, Dept Biol, Ankara, Turkey | en_US |
| dc.contributor.institutionauthor | Özkahraman, Bengi | |
| dc.contributor.institutionauthor | Tamahkar, Emel | |
| dc.identifier.doi | 10.1002/ddr.21747 | |
| dc.authorwosid | Kılıç Süloğlu, Aysun / AAG-4181-2019 | |
| dc.authorwosid | Perçin, Işık / G-9159-2013 | |
| dc.description.wospublicationid | WOS:000574568700001 | en_US |
| dc.description.scopuspublicationid | 2-s2.0-85091851085 | en_US |
| dc.description.pubmedpublicationid | PubMed: 33009868 | en_US |
