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dc.contributor.authorTaşır, Seda
dc.contributor.authorAvcı, Emre
dc.contributor.authorPeker, Emine Gulceri Gulec
dc.contributor.authorCoşkun Cevher, Şule
dc.date.accessioned2021-11-01T15:05:13Z
dc.date.available2021-11-01T15:05:13Z
dc.date.issued2020
dc.identifier.issn2322-1372
dc.identifier.urihttps://doi.org/10.22122/johoe.v9i2.1044
dc.identifier.urihttps://hdl.handle.net/11491/7177
dc.description.abstractBACKGROUND AND AIM: Epidermal growth factor (EGF) plays an important role in the wound healing process. The main purpose of this study is to investigate the effects of EGF on salivary gland oxidative events due to the incision wound created in the oral mucosa. METHODS: In the experiments, 42 New Zealand male rabbits weighing about 2.5 kg were used. Then submucosal incisions were created and subjects were divided into groups: control group (only the incision wound was not applied), untreated incisional group, and EGF therapy group. Subjects were anesthetized on days 1, 3, and 5 after injury and the tissues were removed immediately. Thiobarbituric acid reactive substances (TBARS), the end product of lipid peroxidation, and glutathione (GSH) and ascorbic acid (AA) levels, which are important antioxidants, were measured by spectrophotometric methods in salivary glands. The results were compared with Mann-Whitney U and analysis of variance (ANOVA) tests. RESULTS: The thiobarbituric acid (TBA) reagent levels of the EGF-treated group were found to be significantly reduced on the 1st, 3rd, and 5th days when compared with the data of other group. It was determined that there was a reduction in GSH data from day 1 to day 5 with a similar ratio in both untreated incisional group and EGF therapy group. No statistically significant difference was observed in the days examined within both untreated incisional group and EGF therapy group. CONCLUSION: It was observed that processes including submandibular gland oxidative events and antioxidant responses during wound healing were affected by EGF.en_US
dc.language.isoengen_US
dc.publisherKerman Univ Medical Sciencesen_US
dc.relation.ispartofJournal Of Oral Health And Oral Epidemiologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectSubmandibular Glanden_US
dc.subjectThiobarbituric Acid Reactive Substancesen_US
dc.subjectGlutathioneen_US
dc.subjectAscorbic Aciden_US
dc.titleThe time-dependent effect of exogenous epidermal growth factor administration on oxidant events in submandibular glands of New Zeland-type male rabbitsen_US
dc.typearticleen_US
dc.department[Belirlenecek]en_US
dc.authoridPeker, Gulceri / 0000-0001-7244-0281
dc.identifier.volume9en_US
dc.identifier.issue2en_US
dc.identifier.startpage92en_US
dc.identifier.endpage98en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Tasir, Seda] Ankara Univ, Biotechnol Inst, Ankara, Turkey; [Avci, Emre] Hitit Univ, Sch Arts & Sci, Dept Mol Biol & Genet, Corum, Turkey; [Peker, Emine Gulceri Gulec] Giresun Univ, Sch Hlth Sci, Giresun, Turkey; [Cevher, Sule Coskun] Gazi Univ, Sch Arts & Sci, Dept Biol, Ankara, Turkeyen_US
dc.contributor.institutionauthor[Belirlenecek]
dc.identifier.doi10.22122/johoe.v9i2.1044
dc.authorwosidPeker, Gulceri / AAR-6898-2021
dc.description.wospublicationidWOS:000608118300006en_US


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