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dc.contributor.authorGokcinar, Nesrin Buyuktortop
dc.contributor.authorButurak, Sadiye Visal
dc.contributor.authorOzkal, Fatma
dc.contributor.authorOzcicek, Gamze
dc.contributor.authorYumusak, Mehmet Erhan
dc.contributor.authorTurgal, Ebru
dc.date.accessioned2021-11-01T15:05:05Z
dc.date.available2021-11-01T15:05:05Z
dc.date.issued2020
dc.identifier.issn1758-5864
dc.identifier.issn1758-5872
dc.identifier.urihttps://doi.org/10.1111/appy.12394
dc.identifier.urihttps://hdl.handle.net/11491/7095
dc.description.abstractIntroduction Neuroimaging studies of patients with bipolar disorder (BD) have recently revealed neurodegenerative changes in the central nervous system. Optical coherence tomography (OCT) imaging of the retina, as an extension of brain, may be a biomarker in understanding the neurobiology of the disease. To assess OCT as a tool to detect neurodegeneration in BD we compared the retinal changes between patients with BD and healthy individuals. Methods We performed complete ophthalmological examinations and took OCT images for 70 eyes of 70 patients with BD, and for age and sex-matched individual controls. We compared retinal nerve fiber layers (RNFLs) and total retinal (TR) thickness in the peripapillary areas; and ganglion cell complexes (GCCs) and TR thickness in the maculas between the groups. Results The mean age of the patients was 40.41 +/- 13.22 years and that of the controls 40.20 +/- 13.03 years. The men/women ratios were 37/33 in both groups. BD was significantly associated with a decrease in the average peripapillary RNFL, with the average peripapillary TR, and with the average GCC thickness (P = .033, P = .008, and P = .009, respectively). The peripapillary RNFL and TR thinnings were prominent in the superior (P = .039, P = .033, respectively) and inferior quadrants (P = .031, P = .018, respectively). The BD effects on GCC thinning was prominent in the superior half (P = .001) and in the nasal sectors (except in the inner superonasal sector; all P < .05). BD was associated with a decrease in macular TR thickness only at the inner superior sector (P = .014). Disease duration was inversely correlated with the peripapillary RNFL, TR, and macular GCC thicknesses (P < .05). Discussion Our findings support the neurodegeneration hypothesis in the etiopathogenesis of BD. OCT, a non-invasive neuro-imaging method, may be useful for BD diagnosis and follow-ups.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination UnitKirikkale University [2018/087]en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination Unit, Grant/Award Number: 2018/087en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofAsia-Pacific Psychiatryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbipolar disorderen_US
dc.subjectganglion cell complexen_US
dc.subjectneurodegenerationen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectretinaen_US
dc.titleOptical coherence tomography neurodegenerative findings in patients with bipolar disorderen_US
dc.typearticleen_US
dc.department[Belirlenecek]en_US
dc.authoridGokcinar, Nesrin Buyuktortop / 0000-0001-7795-5188
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Gokcinar, Nesrin Buyuktortop; Ozkal, Fatma; Yumusak, Mehmet Erhan] Kirikkale Univ, Fac Med, Dept Ophthalmol, Yahsihan, Kirikkale, Turkey; [Buturak, Sadiye Visal; Ozcicek, Gamze] Kirikkale Univ, Fac Med, Dept Psychiat, Yahsihan, Kirikkale, Turkey; [Turgal, Ebru] Hitit Univ, Fac Med, Dept Biostat, Corum, Turkeyen_US
dc.contributor.institutionauthor[Belirlenecek]
dc.identifier.doi10.1111/appy.12394
dc.authorwosidGokcinar, Nesrin Buyuktortop / I-8273-2012
dc.description.wospublicationidWOS:000535250900001en_US
dc.description.scopuspublicationid2-s2.0-85085563532en_US
dc.description.pubmedpublicationidPubMed: 32452640en_US


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