Histopathological results of high risk HPV DNA detected patients

Abstract

Objective: In our study, it was aimed to compare histopathologic results and HPV subtypes of the patients who were performed colposcopy because of detected HPV DNA positivity in National HPV Screening Program between 2016-2017 years in çorum province. Methods: All women aged 30-65 years who performed colposcopic biopsy cause of HPV DNA positivity were included in the study. HPV types were divided into three categories as types 16, 18 and others. Pathology results of colposcopic biopsy materials were categorized as Normal, Low grade squamous intraepithelial lesion (CIN I) and high grade squamous intraepithelial lesion (CIN II/III). Results: A total of 212 patients detected HPV DNA positivity, were performed cervical biopsy accompanied by colposcopy. When distributed according to HPV types; HPV types 16, 18 and others were found to be positive in 126, 13 and 73 individuals, respectively. As a result of colposcopy, HSIL were detected in 63 patients (29%), LSIL were detected in 56 patients (26%) and no dysplasia was detected in 93 patients (44%). LSIL were detected in 32 (28%) patients with HPV 16, in 3 (24%) patients with HPV 18 and in 20 (28%) patients with other types. HSIL were detected in 39 (31%) patients with HPV 16, in 6 (46%) patients with HPV 18 and in 11 (15%) patients with other subtypes. The percentages of dysplasia (HSIL + LSIL ) were found 79 (62,6%) in HPV 16, 9 (69.2%) in HPV 18 and 31 (42%) in other subtypes. Patients were evaluated according to age range. A positive correlation between the detection rate of dysplasia and age was observed and it was observed that this ratio reached to 68% in the age range of 60-65 years. Conclusion: The probability of detecting dysplasia in colposcopic biopsies of patients with positive HPV 16 and 18 are higher than other subtypes. Therefore, these patients have to be absolutely evaluated with colposcopic biopsy. The incidence of HPV DNA decreases with age. However, colposcopy have to be performed immediately when HPV positivity is detected especially in the 5th and 6th decades because the percentage of dysplasia detection increases with age. © 2019, Refik Saydam National Public Health Agency (RSNPHA).