Novel palladium (II) complexes of N-(5-nitro-salicylidene)-Schiffbases: Synthesis, spectroscopic characterization and cytotoxicity investigation

Abstract

A series of palladium(II) complexes (1ee3e) with the general formulae [Pd(L)(H2O)]$xH2O were newlysynthesized by the interaction of palladium(II) chloride and the monosodium salts ofN-(5-nitro-sali-cylidene)-Schiff base ligands (1ae3a) in aqueous DMF solution. The identities of all the complexes wereproven by elemental analysis, FTIR,1H,13CNMR,LCeMS, UVevis, XPS, powder XRD spectra, thermalanalysis, conductivity and magnetic susceptibility measurements. The obtained analytical and physico-chemical results exhibited a square-planar coordination of the palladium(II) ion having a doubledeprotonated ligand and a coordinated water molecule.In vitrocytotoxicity of these Pd(II) complexeswas screened against tumor cell lines (HeLa and MCF-7), and a normal human cell line (HEK-293). Thecomplexes 1e and 2e exhibited a moderate antitumor activity against HeLa cell lines, while 3e had betteractivity than standard anticancer drug, doxorubicin. All three complexes showed the best active cyto-toxicity than doxorubicin against MCF-7 cancer lines. For HEK-293 lines, a decrease in concentration ofthe complexes significantly decreased their toxicity.