Spectrophotometric determination of acidity constants of some novel methotrexate-like compounds in water and acetonitrile-water binary mixtures

Abstract

The acidity constants of four novel methotrexate like compounds (NPALA; (N-[4-[[2-hydroxy -1-naphtyl)methylene]amino]benzoyl-?-alanin) TPALA; (N-[4-(2-thiophene-aldiminobenzoyl)-?-alanin), SAL-ALA; N-[4-[[2-hydroxyphenyl)methylene]amino]benzoyl-?-alanin], MeO-SAL-ALA; (N-[4-[[(2-hydroxy-4-methoxyphenyl)metylene]amino]benzoyl-?-alanin)) have been determined in water and acetonitrile-water binary mixtures (10%, and 20% (v/v)) by spectrophotometric method. The effect of the acetonitrile concentration on the ionization constant was also studied.