Yazar "Yılmaz, Akın" için listeleme
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Analysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study
Alp, Ebru; Yılmaz, Akın; Tulmaç, Murat; Uğraş Dikmen, Asiye; Çengel, Atiye; Yalçın, Rıdvan; Menevşe, Emine Sevda (Elsevier (Singapore) Pte Ltd, 2017)Matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) have a significant role in tissue remodeling related to cardiac function. In earlier studies, MMP-7 A-181G (rs11568818), C-153T (rs11568819), ... -
Association of the BsmI, ApaI, TaqI, Tru9I and FokI polymorphisms of the vitamin D receptor gene with nephrolithiasis in the Turkish population
Çakır, Ömer Onur; Yılmaz, Akın; Demir, Emre; İncekara, Kutluhan; Köse, Mustafa Onur; Ersoy Tunalı, Nagehan (Urology and Nephrology Research Centre, 2016)Purpose: To analyze the relationship between nephrolithiasis and vitamin D receptor (VDR) gene BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), Tru9I (rs757343) and FokI (rs2228570) polymorphisms in a study group from ... -
Carboxylesterase 1, alpha 2a adrenergic receptor and noradrenalin transporter gene polymorphisms and their clinical effects in attention deficit hyperactivity disorder in Turkish children
Çetin, Fatih Hilmi; Işık, Yasemen; Alp, Ebru; Yılmaz, Akın; Taş Torun, Yasemen; Önen, İlke Hacer (ScienceDirect, 2018-06)The objective of this study was to examine the association between ADHD and G1287A polymorphism in the NET1 gene, C1291G polymorphism in the ADRA2A gene on the adrenergic pathway and Gly143Glu polymorphism in the CES1 gene ... -
EF24’ün Dosetaksel ile Sıralı Uygulanmasının Metastatik Meme Kanser Hücre Hattına Etkisi
Sağlam, Atiye Seda Yar; Elmazoğlu, Zübeyir; Kayhan, Handan; Yılmaz, Akın; Menevşe, Emine Sevda; Önen, Hacer İlke (2018)Amaç: Taksan sınıfı antineoplastik bir ajan olan dosetaksel, son yılların en önemli kemoterapötik ajanlarından biridir. Günümüzde, meme kanseri tedavisi için klasik kemoterapi ajanlarının yeni moleküller ile birlikte ... -
Effects of EF-24, RAD001, and paclitaxel on the expression profiles of apoptotic and anti-apoptotic genes
Alp, Ebru; Yılmaz, Akın; Önen, İlke Hacer; Menevşe, Emine Sevda (Wolters Kluwer - Medknow, 2017)Context: Cancer cells exert differential responses to chemotherapeutics and inhibitors. To the best of our knowledge, a few or no research has been performed until now to determine the effect of EF-24 and RAD001 on MDA-MB-231 ... -
HDAC inhibitors, MS-275 and salermide, potentiates the anticancer effect of EF24 in human pancreatic cancer cells
Yar Sağlam, Atiye Seda; Yılmaz, Akın; Önen, İlke Hacer; Alp, Ebru; Kayhan, Handan; Ekmekci, Abdullah (Leibniz Research Centre for Working Environment and Human Factors, 2016)Histone deacetylases (HDACs) play a major role in the regulation of chromatin structure and gene expression by changing acetylation status of histone and non-histone proteins. MS-275 (entinostat, MS) is a well-known ... -
HeLa hücrelerinde Sisplatinin MTOR, AKT, CCND1 ve STAT3 mRNA ifadesi üzerine etkileri
Alp, Ebru; Yılmaz, Akın; Önen, Hacer İlke; Konaç, Ece; Ekmekçi, Abdullah; Menevşe, Emine Sevda; Menevşe, Adnan (Gazi Üniversitesi, 2020)Giriş: Serviks kanseri, kadınlarda gözlenen malign tümörler arasında en yaygın görülen ve kadınlarda kanser sonucu gözlenen ölümler arasında ikinci sırada bulunan önemli bir hastalıktır. Platin temelli bir bileşik olan ... -
In Silico Prediction of the Effects of Nonsynonymous Single Nucleotide Polymorphisms in the Human Catechol-O-Methyltransferase (COMT) Gene
Yılmaz, Akın; Çetin, İhsan (Humana Press Inc, 2020)Catechol-O-methyltransferase (COMT) enzyme performs transfer of methyl group to endogenous and exogenous catechol substrates. The COMT enzyme draws interest because of its association with psychiatric, neurological and ... -
Investigating AXIN1 gene polymorphisms in Turkish children with cryptorchidism: A pilot study
Doğan, Gül; Yılmaz, Akın; İpek, Hülya; Metin, Mehmet; Peltek Kendirci, Havva Nur; Afşarlar, Çağatay Evrim (ELSEVIER SCI LTD, 2024)Introduction Cryptorchidism is one of the most common congenital anomalies in male children, occurring in 2e5% of full-term male infants. Both genetic and environmental factors are observed to play a role in its etiology. ... -
Reduced BCL2 and CCND1 mRNA expression in human cervical cancer HeLa cells treated with a combination of everolimus and paclitaxel
Yılmaz, Akın; Alp, Ebru; Önen, İlke Hacer; Menevşe, Emine Sevda (Termedia Publishing House Ltd., 2016)Aim of the study: Cervical cancer is the second most common malignancy in women worldwide. Everolimus displays direct effects on growth and proliferation of cancer cells via inhibition of mammalian target of rapamycin ...
